Research in our laboratory is focused on determining the link between synaptic plasticity and the mechanisms of learning and memory. Activity driven modification of excitatory synapses is a powerful process for the refinement of synaptic connections, which must occur in precise ways for the correct development and ongoing function of the brain. Long-term potentiation (LTP) of synapses is widely accepted to be integral to the formation and consolidation of memories. Using an array of novel mouse mutants, we are mapping out the important receptors and molecules that are required for synaptic plasticity. A complete description of these fundamental processes will allow us to understand the pathology of neurodevelopmental and neuropsychiatric disorders that result in the disruption of memory storage and retrieval.
For a more detailed research description, please visit our lab web page.