Catherine Woolley William Deering Professor
Our research focuses on steroid regulation of synaptic structure and function and the consequences of steroid-driven synaptic modulation for behavior. Most of our work is on the hippocampus, a brain region important in learning and memory, epilepsy, and in affective behaviors like anxiety and depression. We use a range of approaches in our studies including molecular biology, biochemistry, light and electron microscopy, in vitro and in vivo electrophysiology, microdialysis, and behavioral assays.
Two ideas driving current work in the lab are: 1) that estrogens are produced not only in periphery as hormones but also directly within the brain as neurosteoids that rapidly modulate synaptic function and behavior, and 2) that some mechanisms of synaptic modulation in non-reproductive parts of the brain differ between the sexes, which is important for understanding how experience or interventions, such as drugs, affect males and females differently.
- Tabatadze N, Smejkalova T, Woolley CS. (2013). Distribution and post-translational modifications of synaptic ERα in the adult female rat hippocampus.Endocrinology, 154(2):819-30.
- Huang GZ, Woolley CS. (2012). Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism.Neuron, 74(5):801-8
- Smejkalova T, Woolley CS. (2010). Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.J Neurosci, 30(48):16137-16148.
- Ledoux VA, Smejkalova T, May RM, Cooke BM, Woolley CS. (2009). Estradiol facilitates the release of Neuropeptide Y to suppress hippocampus-dependent seizures.J Neurosci, 29:1457-1468.
- 2013 William Deering Chair in Biological Sciences, Northwestern University
- 2011 Special Lecture, Society for Neuroscience
- 2007-09 Pioneer Award, Northwestern University Women’s Health Research Institute
- 2007 C.J. Herrick Award, American Association of Anatomists
- 2004-05 Associated Student Government Faculty Honor Roll
- 2003 Weinberg College of Arts and Sciences Distinguished Teaching Award
- 2002-07 W.M. Keck Foundation Distinguished Young Scholar in Medical Research Award
- 2000 Cajal Club Cortical Explorer Prize
- 1998-99 Alfred P. Sloan Research Fellowship