Indira M. Raman Bill and Gayle Cook Professor
Ionic mechanisms of neuronal excitability
Information in the nervous system is transmitted by electrical signals (action potentials) within neurons and by chemical signals between neurons. The research interests of this lab are in studying the biophysical properties of voltage- and ligand-gated ion channels intrinsic to neurons, as well as in understanding the physiological consequences of the different patterns of activity characteristic of specific neurons.
We are currently studying neurons of the cerebellum, a brain region that participates in controlling movements. Projects in the lab focus on the ion channel properties responsible for specific patterns of firing, the transmission of synaptic signals from Purkinje to cerebellar nuclear cells, the responses of cerebellar nuclear cells to different patterns of synaptic input, and the activity and changes in cerebellar neuronal spiking during motor behaviors and learning.
- Lewis AH, Raman IM. (2013). Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaVβ4 open-channel blocking peptide. J Gen Physiol. 142(3):191-206.
- Person AL, Raman IM. (2012). Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature, 481(7382):502-5.
- Lewis AH, Raman IM. (2011). Cross-species conservation of open-channel block by Na channel β4 peptides reveals structural features required for resurgent Na current. J Neurosci, 31(32):11527-36.
- Bant JS, Raman IM. (2010). Control of transient, resurgent, and persistent current by open-channel block by Na channel β4 in cultured cerebellar granule neurons. Proc of the Natl Acad Sci U S A, 107(27):12357-62.
- Person AL, Raman IM. (2010). Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei. Neuron, May 27;66(4):550-9.
- Aman TK, Raman IM. (2010). Inwardly permeating Na ions generate the voltage dependence of resurgent Na current in cerebellar Purkinje neurons. J Neurosci, Apr 21;30(16):5629-34.
- Benton MD, Raman IM. (2009). Stabilization of Ca current in Purkinje neurons during high-frequency firing by a balance of Ca-dependent facilitation and inactivation. Channels (Austin), Nov 13;3(6).
- Zheng N, Raman IM. (2009). Ca currents activated by spontaneous firing and synaptic disinhibition in neurons of the cerebellar nuclei. J Neurosci, Aug 5;29(31):9826-38.
- Pugh JR, Raman IM. (2009). Nothing can be coincidence: synaptic inhibition and plasticity in the cerebellar nuclei. Trends Neurosci, Jan 27.
- Pugh JR, Raman IM. (2008). Mechanisms of potentiation of mossy fiber EPSCs in the cerebellar nuclei by coincident synaptic excitation and inhibition. J Neurosci, 28(42):10549-60.
- Aman T.K., Raman IM. (2007). Subunit dependence of Na channel slow inactivation and open channel block in cerebellar neurons. Biophys J, 92(6):1938-51.
- Pugh J.R., Raman IM. (2006). Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron, Jul 6;51(1):113-23.
- 2014 NINDS Javits Award
- 2013 Installed as Bill And Gayle Cook Professor, Northwestern University
- 2010–13 Charles Deering Mccormick Professor Of Teaching Excellence, Northwestern Univeristy.
- 2009 Integrated Science Program Faculty Service Award, Northwestern University
- 2008 Excellence In Instruction Award, Interdepartmental Neuroscience Graduate Program, Northwestern University
- 2006 Clarence Ver Steeg Award For Graduate Faculty, Northwestern University
- 2004 Distinguished Undergraduate Teaching Award, Weinberg College of Arts and Sciences, Northwestern University
- 2001–04 Joseph And Esther A. Klingenstein Fellowship Award In The Neurosciences
- 2000–03 Searle Foundation Scholarship
- 1999–01 Alfred P. Sloan Foundation Fellowship