Jianhua 'JC' Cang Professor
Organization, Function and Development of Mammalian Visual System
The overall goal of our research is to study the organization, function and development of the visual system. With an integrative approach that combines physiology, functional imaging, genetics, molecular, behavioral, and computational methods, our research is mainly along two directions. First, we made a paradigm-shifting discovery regarding how sensory experience shapes visual functions in the cortex during a critical period in early life. Second, we have carried out a series of functional studies of the mouse superior colliculus, helping to establish it as a new model for studying visual information processing and sensorimotor transformation. We are now continuing both lines of research in mice by performing mechanistic studies of critical period plasticity in the cortex and visual transformation and development in the superior colliculus.
- Wang L, Liu M, Segraves MA, and Cang J. (2015) Visual Experience Is Required for the Development of Eye Movement Maps in the Mouse Superior Colliculus. J Neurosci. 35(35):12281-6.
- Krishnan K*, Wang B-S*, Lu J, Wang L, Maffei A, Cang J, and Huang ZJ. (2015) MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex. Proc Natl Acad Sci U S A. 112(34):E4782-91.
- Inayat S*, Barchini J*, Chen H, Feng L, Liu X, and Cang J. (2015) Neurons in the Most Superficial Lamina of the Mouse Superior Colliculus Are Highly Selective for Stimulus Direction. J Neurosci, 35(20). 7992-8003
- Zhao X*, Liu M*, and Cang J. (2014) Visual cortex modulates the magnitude but not the selectivity of looming-evoked responses in the superior colliculus of awake mice. Neuron, 84(1):202-13.
- Wang B-S, Feng L, Liu M, Liu X, and Cang J. (2013) Environmental Enrichment Rescues Binocular Matching of Orientation Preference in Mice that Have a Precocious Critical Period. Neuron, 80(1):198-209.
- Zhao X, Chen H, Liu X, Cang J. (2013) Orientation-selective Responses in the Mouse Lateral Geniculate Nucleus. J Neurosci, 33(31):12751-63.
- Zhao X, Liu M, Cang J. (2013) Sublinear binocular integration preserves orientation selectivity in mouse visual cortex. Nat Commun, 2013 Jun 26;4:2088. doi: 10.1038/ncomms3088.
- Sarnaik R, Wang B-S, and Cang J. (2013) Experience-Dependent and Independent Binocular Correspondence of Receptive Field Subregions in Mouse Visual Cortex. Cereb Cortex, Epub 2013 Feb 6.
- Grimbert F and Cang J. (2012) New Model of Retinocollicular Mapping Predicts the Mechanisms of Axonal Competition and Explains the Role of Reverse Molecular Signaling during Development. J Neurosci, 11;32(28):9755-68.
- Wang L*, Sarnaik R*, Rangarajan KV, Liu X, and Cang J. (2010) Visual Receptive Field Properties of Neurons in the Superficial Superior Colliculus of the Mouse. J Neurosci, 30(49): 16573-84.
- Wang BS, Sarnaik R, Cang J. (2010). Critical Period Plasticity Matches Binocular Orientation Preference in the Visual Cortex. Neuron, 65(2):246-256.
* Indicates co-first authors.
- 2009-12 Klingenstein Fellowship Award In The Neurosciences
- 2009-10 Brain Research Foundation Seed Grant
- 2008-10 Alfred P. Sloan Foundation Research Fellowship
- 2005-06 Knights Templar Eye Foundation Pediatric Ophthalmology Research Grant
- 2002-05 Life Sciences Research Foundation Postdoctoral Fellowship