Jianhua 'JC' Cang Associate Professor
Functional Development of Mammalian Visual System
The overall goal of our research is to study how precise and selective patterns of neuronal connections are established during development to ensure the normal functioning of the visual system. Using the mouse visual system, we are currently pursuing two related lines of research. First, we have recently demonstrated that normal visual experience during a critical period in early life drives the matching of eye-specific orientation preference in the visual cortex. We are now working to understand the receptive field basis and synaptic mechanisms that underlie this binocular matching process and its temporal regulation. Second, we continue to study how retinotopic maps in the visual cortex and superior colliculus are developed and how these topographically precise connections shape individual receptive fields and contribute to visual motor integration.
- Wang B-S, Feng L, Liu M, Liu X, and Cang J. (2013) Environmental Enrichment Rescues Binocular Matching of Orientation Preference in Mice that Have a Precocious Critical Period. Neuron, 80(1):198-209.
- Zhao X, Chen H, Liu X, Cang J. (2013) Orientation-selective Responses in the Mouse Lateral Geniculate Nucleus. J Neurosci, 33(31):12751-63.
- Zhao X, Liu M, Cang J. (2013) Sublinear binocular integration preserves orientation selectivity in mouse visual cortex. Nat Commun, 2013 Jun 26;4:2088. doi: 10.1038/ncomms3088.
- Sarnaik R, Wang B-S, and Cang J. (2013) Experience-Dependent and Independent Binocular Correspondence of Receptive Field Subregions in Mouse Visual Cortex. Cereb Cortex, Epub 2013 Feb 6.
- Grimbert F and Cang J. (2012) New Model of Retinocollicular Mapping Predicts the Mechanisms of Axonal Competition and Explains the Role of Reverse Molecular Signaling during Development. J Neurosci, 11;32(28):9755-68.
- Wang L*, Sarnaik R*, Rangarajan KV, Liu X, and Cang J. (2010) Visual Receptive Field Properties of Neurons in the Superficial Superior Colliculus of the Mouse. J Neurosci, 30(49): 16573-84.
- Wang BS, Sarnaik R, Cang J. (2010). Critical Period Plasticity Matches Binocular Orientation Preference in the Visual Cortex. Neuron, 65(2):246-256.